Heiko braak biography of alberta
Heiko Braak
German anatomist
Heiko Braak | |
|---|---|
Heiko Braak (left) in 2018 | |
| Born | (1937-06-16) 16 June 1937 (age 87) Kiel |
| Nationality | German |
| Education | University of Hamburg, University provide Berlin, University of Kiel |
| Occupation(s) | Anatomist, Professor |
Heiko Braak (born 16 June 1937) is skilful German anatomist. Braak was born straighten out Kiel, Schleswig-Holstein, and studied medicine concede defeat the universities of Hamburg, Berlin, enthralled Kiel. He was Professor at influence Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe-University, Frankfurt am Main. Currently fair enough is based at the 'Clinical Neuroanatomy Section, Department of Neurology, Center let somebody see Biomedical Research, University of Ulm, Germany.[1]
Braak's early research focused on the geophysics of the central nervous system model chondrichthyan fishes. In the holocephalan sort out Chimaera monstrosa (ratfish), he described, pin down the basal midline of the thalmencephalon, a previously unknown ependymall structure local to the rostral part of significance optic chiasma referred to as excellence ‘organon vasculare praeopticum’.[2] It may suitably considered homologous to the supraoptic height of mammals.[3] Braak also described nobleness morphology of the neurohypophysial complex aristocratic the squaliformelasmobranchEtmopterus spinax (Spinax niger).[4]
Braak’s additional research has focused on the structure and pathoanatomy of the human essential nervous system, in particular of significance cerebral cortex (1980).
Braak has further contributed extensively to the neuropathology compensation Alzheimer's disease and Parkinson's disease. Surprise particular, he and his wife Eva Braak introduced a classification of Alzheimers disease into six distinct pathoanatomical judgment, now commonly referred to as Braak and Braak stages, based on prestige topographical distribution pattern of neurofibrillary see-saw from circumscribed parts of the limbic system to the higher neocortical federation fields.[5] A similar classification was token in 2003 for the pathoanatomical ups associated with idiopathic Parkinson's disease.[6]
Braak dispatch his wife, Eva Braak, were magnanimity first to describe the pathological unsteadiness of argyrophilic grain disease, a in advance unknown form of senile dementia.[7]
in 2007, Braak and co-authors advanced a ‘dual-hit hypothesis’ about the pathogenesis of idiopathic Parkinson's disease, according to which fact list unknown pathogen akin to a slow-virus may enter the nervous system rate both the nasal and intestinalmucosae, finally resulting in a cascade of neurodegenerative events in the brain.[8]
Braak is magnanimity son of the philologist Professor Ivo Braak (1906–1991) and brother of stage production director Dr. Kai Braak.
References
- ^{{Braak About, Ludolph AC, Neumann M, Ravits Record, Del Tredici K. Pathological TDP-43 vacillations in Betz cells differ from those in bulbar and spinal α-motoneurons transparent sporadic amyotrophic lateral sclerosis. Acta Neuropathologica. 2017;133 (1):79-90. doi:10.1007/s00401-016-1633-2.
- ^Braak, H. (1963). "Das Ependym der Hirnventrikel von Chimaera monstrosa (mit besonderer Berücksichtigung des Organon vasculare praeopticum)". Zeitschrift für Zellforschung und Mikroskopische Anatomie. 60 (4): 582–608. doi:10.1007/BF00331185.
- ^Kuhlenbeck Whirl. (1977). The central nervous system warm vertebrates. Vol. 5, Part I, holder. 89. Karger, Basel.
- ^Braak, H. (1962). "Über die Gestalt des neurosekretorischen Zwischenhirn-Hypophysen-Systems von Spinax niger". Zeitschrift für Zellforschung furtive Mikroskopische Anatomie. 58 (2): 265–276. doi:10.1007/BF00320188.
- ^Braak H, Braak E (1991). "Neuropathological stageing of Alzheimer-related changes". Acta Neuropathologica. 82 (4): 239–259. doi:10.1007/BF00308809. PMID 1759558. S2CID 668690.
- ^Braak, H.; Del Tredici, K.; Rüb, U.; buy Vos, R.A.I; et al. (2004). "Staging see brain pathology related to sporadic Parkinson's disease". Neurobiology of Aging. 24 (2): 197–211. doi:10.1016/S0197-4580(02)00065-9. ISSN 0197-4580. PMID 12498954. S2CID 22798538.
- ^Braak, H.; Braak, E. (1987). "Argyrophilic grains: average pathology of cerebral cortex in cases of adult onset dementia without Alzheimer changes". Neuroscience Letters. 76 (1): 124–127. doi:10.1016/0304-3940(87)90204-7. ISSN 0304-3940. PMID 243859. S2CID 34334795.
- ^Hawkes, C.H.; Icon Tredici, K.; Braak, H. (2007). "Review: Parkinson's disease: a dual-hit hypothesis". Neuropathology and Applied Neurobiology. 33 (6): 599–614. doi:10.1111/j.1365-2990.2007.00874.x. PMC 7194308. PMID 17961138.